血小板和胎盘酚磺基转移酶对β2肾上腺素能受体激动剂的硫酸酯结合作用
Sulphate conjugation of beta 2-adrenoceptor stimulating drugs by platelet and placental phenol sulphotransferase.
作者信息
Sodha R J, Schneider H
出版信息
Br J Clin Pharmacol. 1984 Jan;17(1):106-8. doi: 10.1111/j.1365-2125.1984.tb05009.x.
Abstract
A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were found to be relatively similar to those obtained with the catecholamine dopamine but their Km values were considerably higher.
摘要
产科中使用的β-肾上腺素能受体激动剂的一种可能代谢途径是通过酚磺基转移酶进行结合反应。对血小板和胎盘酶对这些药物的底物特异性进行了检测。发现β-肾上腺素能受体激动剂的比活性与儿茶酚胺多巴胺的比活性相对相似，但其米氏常数要高得多。
相似文献
1
Sulphate conjugation of beta 2-adrenoceptor stimulating drugs by platelet and placental phenol sulphotransferase.血小板和胎盘酚磺基转移酶对β2肾上腺素能受体激动剂的硫酸酯结合作用
Br J Clin Pharmacol. 1984 Jan;17(1):106-8. doi: 10.1111/j.1365-2125.1984.tb05009.x.
2
Sulphate conjugation of p-hydroxytriamterene by platelet phenol sulphotransferase: assay conditions and correlation with metabolism in man.血小板酚磺基转移酶对对羟基氨苯蝶啶的硫酸结合作用：测定条件及其与人体代谢的相关性
Br J Clin Pharmacol. 1983 Feb;15(2):211-20. doi: 10.1111/j.1365-2125.1983.tb01488.x.
3
Multiple forms of phenolsulphotransferase in human tissues: selective inhibition by dichloronitrophenol.人体组织中酚磺基转移酶的多种形式：二氯硝基苯酚的选择性抑制作用
Biochem Pharmacol. 1982 May 15;31(10):1893-7. doi: 10.1016/0006-2952(82)90493-2.
4
alpha-Methyldopa, alpha-methyldopamine an alpha-methylnoradrenaline: substrates for the thermolabile form of human platelet phenol sulphotransferase.α-甲基多巴、α-甲基多巴胺和α-甲基去甲肾上腺素：人血小板酚磺基转移酶热不稳定形式的底物。
Br J Clin Pharmacol. 1982 Aug;14(2):231-9. doi: 10.1111/j.1365-2125.1982.tb01967.x.
5
Human platelet phenol sulphotransferase: assay procedure, substrate and tissue correlations.人血小板酚磺基转移酶：测定方法、底物与组织的相关性
Clin Chim Acta. 1981 Mar 5;110(2-3):157-67. doi: 10.1016/0009-8981(81)90345-4.
6
Human platelet phenolsulphotransferase M and P: substrate specificities and correlation with in vivo sulphoconjugation of paracetamol and salicylamide.人血小板酚磺基转移酶M和P：底物特异性及其与对乙酰氨基酚和水杨酰胺体内硫酸结合反应的相关性
Br J Clin Pharmacol. 1983 Mar;15(3):323-30. doi: 10.1111/j.1365-2125.1983.tb01506.x.
7
Assay of phenol sulphotransferase in human blood.人体血液中酚磺基转移酶的测定
Clin Chim Acta. 1983 Oct 31;134(1-2):199-206. doi: 10.1016/0009-8981(83)90197-3.
8
Enzymic sulphation of dopa and tyrosine isomers by HepG2 human hepatoma cells: stereoselectivity and stimulation by Mn2+.人肝癌细胞HepG2对多巴和酪氨酸异构体的酶促硫酸化作用：立体选择性及锰离子的刺激作用
Biochem J. 1996 Feb 15;314 ( Pt 1)(Pt 1):151-8. doi: 10.1042/bj3140151.
9
Phenol sulfotransferase in humans: properties, regulation, and function.人类中的酚磺基转移酶：特性、调节与功能。
Fed Proc. 1986 Jul;45(8):2223-8.
10
Sulphate conjugation of biologically active monoamines and their metabolites by human platelet phenolsulphotransferase.人血小板酚磺基转移酶对生物活性单胺及其代谢产物的硫酸结合作用。
Clin Chim Acta. 1981 Apr 9;111(2-3):247-56. doi: 10.1016/0009-8981(81)90192-3.
引用本文的文献
1
MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells.MRP 同工型和 BCRP 介导硫酸盐缀合物从 BeWo 细胞中流出。
Int J Pharm. 2010 Jan 15;384(1-2):15-23. doi: 10.1016/j.ijpharm.2009.09.033. Epub 2009 Sep 25.
2
Expression and functional activities of selected sulfotransferase isoforms in BeWo cells and primary cytotrophoblast cells.BeWo细胞和原代细胞滋养层细胞中特定硫酸转移酶亚型的表达及功能活性
Biochem Pharmacol. 2009 Dec 15;78(12):1475-82. doi: 10.1016/j.bcp.2009.07.013. Epub 2009 Jul 30.
3
Drug transfer and metabolism by the human placenta.药物在人胎盘的转运与代谢。
Clin Pharmacokinet. 2004;43(8):487-514. doi: 10.2165/00003088-200443080-00001.
4
Models for placental transfer studies of drugs.药物胎盘转运研究模型。
Clin Pharmacokinet. 1995 Feb;28(2):161-80. doi: 10.2165/00003088-199528020-00006.
5
Stereoselective sulphate conjugation of racemic terbutaline by human liver cytosol.人肝细胞溶质对外消旋特布他林的立体选择性硫酸酯化作用。
Br J Clin Pharmacol. 1990 Jul;30(1):127-33. doi: 10.1111/j.1365-2125.1990.tb03752.x.
6
Clinical pharmacokinetics of beta-agonists.β-激动剂的临床药代动力学
Clin Pharmacokinet. 1990 Apr;18(4):270-94. doi: 10.2165/00003088-199018040-00002.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Human platelet phenolsulphotransferase: separate control of the two forms and activity range in depressive illness.人血小板酚磺基转移酶：抑郁症中两种形式的独立调控及活性范围
Clin Chim Acta. 1981 Dec 24;117(3):333-44. doi: 10.1016/0009-8981(81)90121-2.
3
Multiple forms of phenolsulphotransferase in human tissues: selective inhibition by dichloronitrophenol.人体组织中酚磺基转移酶的多种形式：二氯硝基苯酚的选择性抑制作用
Biochem Pharmacol. 1982 May 15;31(10):1893-7. doi: 10.1016/0006-2952(82)90493-2.
4
Sulphate conjugation of biologically active monoamines and their metabolites by human platelet phenolsulphotransferase.人血小板酚磺基转移酶对生物活性单胺及其代谢产物的硫酸结合作用。
Clin Chim Acta. 1981 Apr 9;111(2-3):247-56. doi: 10.1016/0009-8981(81)90192-3.
5
Phenolsulphotransferase in human placenta.人胎盘中的酚磺基转移酶
Biochem Pharmacol. 1983 May 15;32(10):1655-7. doi: 10.1016/0006-2952(83)90345-3.
6
[Pharmacokinetic studies on 3H-hexoprenaline in the rat].[大鼠体内3H-己氧去甲肾上腺素的药代动力学研究]
Arzneimittelforschung. 1973 May;23(5):721-9.
7
The metabolism of terbutaline in vitro by rat and human liver O-methyltransferases and monoamine oxidases.特布他林在体外经大鼠和人肝脏O-甲基转移酶及单胺氧化酶的代谢。
Xenobiotica. 1972 Jul;2(4):375-82. doi: 10.3109/00498257209111064.
Zotero 插件