耳蜗毛细胞对谷氨酰胺的优先摄取：对耳蜗传入神经递质的影响。

Preferential glutamine uptake by cochlear hair cells: implications for the afferent cochlear transmitter.

作者信息

Ryan A F, Schwartz I R

出版信息

Brain Res. 1984 Jan 9;290(2):376-9. doi: 10.1016/0006-8993(84)90960-0.

Abstract

The cochlear uptake of amino acids which are putative neurotransmitters, or closely-related compounds, was examined autoradiographically in the gerbil. Hair cells showed no preferential uptake of most compounds tested. However, preferential accumulation of glutamine by cochlear hair cells was striking. Vestibular hair cells showed no affinity for this amino acid. Glutamine uptake by cochlear hair cells may play an important role in afferent synaptic transmission, by providing transmitter precursor and/or by clearing the synaptic cleft.

摘要

采用放射自显影术在沙鼠中检测了耳蜗对作为假定神经递质或密切相关化合物的氨基酸的摄取情况。毛细胞对所测试的大多数化合物没有优先摄取。然而，耳蜗毛细胞对谷氨酰胺的优先积累非常显著。前庭毛细胞对这种氨基酸没有亲和力。耳蜗毛细胞对谷氨酰胺的摄取可能通过提供递质前体和/或清除突触间隙，在传入突触传递中发挥重要作用。