β-肾上腺素能受体激动剂的离子化：一种解析离子化方案的方法。
The ionization of beta-adrenoceptor agonists: a method for unravelling ionization schemes.
作者信息
Ijzerman A P, Bultsma T, Timmerman H, Zaagsma J
出版信息
J Pharm Pharmacol. 1984 Jan;36(1):11-5. doi: 10.1111/j.2042-7158.1984.tb02978.x.
Abstract
To investigate the ionization schemes of beta-adrenoceptor agonists, a combined electrochemical/uv-spectrophotometric method with computer-assisted data-analysis was developed, yielding the macroscopic and microscopic ionization constants. From the four species possible, cations and zwitterions were found the main species present at physiological pH, the formation of uncharged molecules and anions being less favourable or apparently negligible.
摘要
为了研究β-肾上腺素能受体激动剂的电离方案，开发了一种结合电化学/紫外分光光度法并采用计算机辅助数据分析的方法，得到了宏观和微观电离常数。在可能存在的四种物种中，发现阳离子和两性离子是生理pH下的主要存在物种，不带电荷的分子和阴离子的形成不太有利或明显可以忽略不计。
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