前列腺素在豚鼠回肠纵肌条神经肌肉接头处强直后增强中的可能作用。

Possible role of prostaglandins in post-tetanic potentiation at the nerve-muscle junction in the longitudinal muscle strip of guinea-pig ileum.

作者信息

Kadlec O, Masek K, Růzicka V, Seferna I

出版信息

J Pharm Pharmacol. 1984 Jan;36(1):65-8. doi: 10.1111/j.2042-7158.1984.tb02994.x.

DOI:10.1111/j.2042-7158.1984.tb02994.x

Abstract

The effect of tetanic stimulation on the twitch responses of the longitudinal muscle-myenteric plexus preparation of the guinea-pig ileum to electrical stimulation was investigated in the presence of naloxone. Under this condition, or after the addition of PGE2, twitch contractions were maximal and no potentiation of twitches following tetanus was observed. In the presence of indomethacin (1 mumol litre-1) twitches were diminished and post-tetanic potentiation (PTP) was manifested. PTP was seen with indomethacin concentrations of 1 to 20 mumol litre-1 or after simultaneous addition of diphloretin phosphate (16 mumol litre-1). Thus it seems unlikely that the effect of prostaglandins released during tetanic stimulation would be of key importance for the manifestation of PTP. Rather it is thought that a decrease in the release of acetylcholine from motor nerve terminals, and consequently smaller twitches in the presence of indomethacin, offer favourable conditions for PTP.

摘要

在纳洛酮存在的情况下，研究了强直刺激对豚鼠回肠纵肌-肠肌丛标本对电刺激的抽搐反应的影响。在这种情况下，或添加前列腺素E2后，抽搐收缩达到最大值，未观察到强直刺激后抽搐的增强。在吲哚美辛（1微摩尔/升）存在的情况下，抽搐减弱并出现强直后增强（PTP）。在吲哚美辛浓度为1至20微摩尔/升时或同时添加磷酸二氢黄酮（16微摩尔/升）后可观察到PTP。因此，强直刺激期间释放的前列腺素的作用似乎不太可能对PTP的表现起关键作用。相反，人们认为运动神经末梢乙酰胆碱释放的减少，以及因此在吲哚美辛存在下较小的抽搐，为PTP提供了有利条件。