疼痛生理学综述

The physiology of pain: a review.

作者信息

Edmeads J

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):413-9. doi: 10.1016/0278-5846(83)90004-0.

Abstract

Pain is a complex physiological phenomenon that begins with the stimulation of free nerve endings in peripheral tissues and culminates in the perception of a physical and psychological state. The pain experience may be facilitated or inhibited through the action of several neurologic circuits which utilize several neurotransmitters. Therapeutic analgesia is achieved either through interference with pain-facilitating mechanisms or enhancement of pain-inhibiting mechanisms; practical applications are reviewed.

摘要

疼痛是一种复杂的生理现象，始于外周组织中游离神经末梢的刺激，最终表现为一种生理和心理状态的感知。疼痛体验可通过利用多种神经递质的几种神经回路的作用而得到促进或抑制。治疗性镇痛可通过干扰疼痛促进机制或增强疼痛抑制机制来实现；本文对实际应用进行了综述。