Ahrén B, Lundquist I, Järhult J
Acta Endocrinol (Copenh). 1984 Jan;105(1):78-82. doi: 10.1530/acta.0.1050078.
The effects of alpha- and beta-adrenoceptor blockade on plasma concentrations of insulin and glucose were studied in the anaesthetized rat. Infusion of the alpha 1-adrenoceptor blocker prazocin (80 micrograms/min), the alpha 2-adrenoceptor blocker yohimbine (15 micrograms/min) or the non-selective alpha-adrenoceptor blocker phentolamine (15 micrograms/min) during 50 min increased plasma insulin levels by about 1.5-2.5 ng/ml. The effects of phentolamine and prazosin on circulating insulin persisted throughout the infusion whereas the effect of yohimbine seemed to be more transient. Plasma glucose levels increased slightly during infusion of prazosin, but tended to decrease in response to phentolamine and yohimbine. The beta-adrenoceptor blocker propranolol (15 micrograms/min) lowered basal plasma insulin and glucose levels. It also depressed plasma insulin during infusion of all three alpha-adrenoceptor blockers without any appreciable influence on plasma glucose. It is suggested that both alpha 1- and alpha 2-adrenoceptor as well as beta-adrenoceptors are involved in the regulation of basal insulin secretion in the rat.
在麻醉大鼠中研究了α和β肾上腺素能受体阻断对胰岛素和葡萄糖血浆浓度的影响。在50分钟内输注α1肾上腺素能受体阻滞剂哌唑嗪（80微克/分钟）、α2肾上腺素能受体阻滞剂育亨宾（15微克/分钟）或非选择性α肾上腺素能受体阻滞剂酚妥拉明（15微克/分钟），可使血浆胰岛素水平升高约1.5 - 2.5纳克/毫升。酚妥拉明和哌唑嗪对循环胰岛素的作用在整个输注过程中持续存在，而育亨宾的作用似乎更短暂。输注哌唑嗪期间血浆葡萄糖水平略有升高，但对酚妥拉明和育亨宾的反应则趋于降低。β肾上腺素能受体阻滞剂普萘洛尔（15微克/分钟）降低基础血浆胰岛素和葡萄糖水平。在输注所有三种α肾上腺素能受体阻滞剂期间，它也会降低血浆胰岛素水平，而对血浆葡萄糖没有明显影响。提示α1和α2肾上腺素能受体以及β肾上腺素能受体均参与大鼠基础胰岛素分泌的调节。
