Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Bethesda, Maryland, USA.
Pediatr Diabetes. 2022 Dec;23(8):1567-1578. doi: 10.1111/pedi.13430. Epub 2022 Oct 14.
Metabolic disease risk in youth is influenced by sedentary behaviors. Acute in-lab studies show that, during a single day, interrupting a sedentary period with short bouts of physical activity improves glucometabolic outcomes.
To determine if acutely improved glucose metabolism persists after multi-day interruptions of sitting with walking brief bouts. We hypothesized that children who underwent interrupting sitting on multiple days would demonstrate lower insulin area under the curve during an oral glucose tolerance test compared to uninterrupted sitting.
Healthy, normoglycemic children (N = 109) ages 7-11 years were randomized to one of two conditions: Control (3 h of daily Uninterrupted Sitting) or Interrupted Sitting (3-min of moderate-intensity walking every 30 min for 3 h daily); with dietary intake controlled through provision of foodstuffs for the entire experiment. Participants attended six consecutive daily visits at a research ambulatory unit. The primary outcome was insulin area under the curve during the oral glucose tolerance test on day 6 during interrupted or uninterrupted sitting; secondary outcomes included glucose and c-peptide area under the curve, energy intake at a buffet meal on day 6, and free-living activity.
Among 93 children (42 uninterrupted sitting, 51 interrupted sitting), daily interrupted sitting resulted in 21% lower insulin (β = 0.102 CI:0.032-0.172, p = 0.005) and a 10% lower C-peptide (β = 0.043, CI:0.001-0.084, p = 0.045) area under the curve. Matsuda and Glucose Effectiveness Indices were also improved (p's < 0.05). There were no group differences in energy intake or expenditure.
Sustained behavioral change by interrupting sedentary behaviors is a promising intervention strategy for improving metabolic risk in children.
年轻人的代谢疾病风险受久坐行为的影响。急性实验室研究表明，在一天内，用短暂的体力活动打断久坐时间可改善糖代谢结果。
确定多天中断坐姿并用短暂步行打断后，急性改善的葡萄糖代谢是否持续。我们假设，与不间断坐姿相比，在多天中断坐姿的儿童在口服葡萄糖耐量试验中胰岛素曲线下面积会更低。
健康、血糖正常的儿童（N=109）年龄为 7-11 岁，随机分为以下两种情况之一：对照组（每天 3 小时不间断坐姿）或间断坐姿组（每天 3 小时内每 30 分钟进行 3 分钟中等强度步行）；通过提供整个实验所需的食物来控制饮食摄入。参与者在研究活动单元连续六天就诊。主要结局是在第 6 天的口服葡萄糖耐量试验中，在中断或不间断坐姿时的胰岛素曲线下面积；次要结局包括葡萄糖和 C 肽曲线下面积、第 6 天自助餐的能量摄入以及自由活动。
在 93 名儿童（42 名不间断坐姿，51 名间断坐姿）中，每天间断坐姿导致胰岛素（β=0.102 CI：0.032-0.172，p=0.005）和 C 肽（β=0.043，CI：0.001-0.084，p=0.045）曲线下面积分别降低 21%和 10%。Matsuda 和葡萄糖效能指数也有所改善（p<0.05）。两组间的能量摄入或消耗没有差异。
通过打断久坐行为来维持行为改变是改善儿童代谢风险的一种很有前途的干预策略。
