Pradhan S
Arch Int Pharmacodyn Ther. 1983 Dec;266(2):221-8.
Acute administration of cocaine (20 mg/kg, i.p.) stimulated activity of striatal tyrosine hydroxylase (TH) which reached its maximum level at 10 min and returned to normal between 20-40 min. However, tryptophan hydroxylase (TPH) activity in the pons-medulla was reduced to a minimum at 10 min after its injection and returned to normal between 20-40 min. Activity of monoamine oxidase (MAO) was significantly reduced at 10 min and increased MAO (Type A) at 20 min showing a biphasic effect of cocaine on this enzyme. Relation of the time-courses of cocaine effects on the activity of these enzymes and the levels of related neurotransmitters is discussed.
腹腔注射可卡因（20毫克/千克）后，纹状体酪氨酸羟化酶（TH）的活性受到刺激，在10分钟时达到最高水平，并在20 - 40分钟之间恢复正常。然而，脑桥-延髓中的色氨酸羟化酶（TPH）活性在注射后10分钟降至最低，并在20 - 40分钟之间恢复正常。单胺氧化酶（MAO）的活性在10分钟时显著降低，在20分钟时MAO（A型）增加，表明可卡因对该酶有双相作用。文中讨论了可卡因对这些酶活性和相关神经递质水平影响的时间进程关系。
