Lehotay D C, Levey B A, Levey G S
Biomed Pharmacother. 1983;37(7):312-6.
Doxorubicin, an anthracycline antibiotic and antitumor agent, has cardiotoxic side-effects that limit its therapeutic usefulness. We have demonstrated that the drug inhibits cardiac guanylate cyclase activity in vitro. The biochemical changes following anthracycline treatment are described, and the various hypotheses attempting to account for cardiotoxicity in terms of a molecular mechanism are reviewed. It is suggested that inhibition of cardiac guanylate cyclase activity may be a consequence of the increase in free radicals and oxidative damage following treatment with doxorubicin or related compounds.
阿霉素是一种蒽环类抗生素和抗肿瘤药物，具有心脏毒性副作用，这限制了其治疗效用。我们已经证明，该药物在体外可抑制心脏鸟苷酸环化酶的活性。本文描述了蒽环类药物治疗后的生化变化，并综述了试图从分子机制角度解释心脏毒性的各种假说。有人认为，心脏鸟苷酸环化酶活性的抑制可能是阿霉素或相关化合物治疗后自由基增加和氧化损伤的结果。
