关于拉氏蝴蝶丽鱼（硬骨鱼纲，丽鱼科）黑素细胞受体的研究。
A study on melanophore receptors of Papiliochromis ramirezi (Teleostei, Cichlidae).
作者信息
Visconti M A, Castrucci A M, Valente D
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(1):161-5. doi: 10.1016/0742-8413(84)90146-4.
Melanophores of Papiliochromis ramirezi aggregate their melanosomes in the presence of catecholamines. Their order of potency are: at 10(-4) M, norepinephrine greater than isoproterenol = epinephrine; at 10(-6) and 10(-8) M, norepinephrine = isoproterenol greater than epinephrine. These effects are antagonized not only by phentolamine but also by propranolol. The catecholamines are unable to induce pigment dispersion. Melanosome dispersion is obtained with cholinergic drugs and the order of potency is nicotine greater than acetylcholine = pilocarpine. Their effects are inhibited by atropine and also by d-tubocurarine and potentiated by physostigmine. The evidences suggest the presence of undifferentiated adrenoceptors, related to the melanosome aggregation and undifferentiated cholinoceptors related to the melanosome dispersion.
拉氏蝴蝶丽鱼（Papiliochromis ramirezi）的黑素细胞在儿茶酚胺存在的情况下会聚集其黑素小体。它们的效力顺序为：在10⁻⁴ M时，去甲肾上腺素＞异丙肾上腺素 = 肾上腺素；在10⁻⁶和10⁻⁸ M时，去甲肾上腺素 = 异丙肾上腺素＞肾上腺素。这些效应不仅被酚妥拉明拮抗，也被普萘洛尔拮抗。儿茶酚胺无法诱导色素分散。用胆碱能药物可实现黑素小体分散，效力顺序为尼古丁＞乙酰胆碱 = 毛果芸香碱。它们的效应被阿托品抑制，也被d - 筒箭毒碱抑制，并被毒扁豆碱增强。证据表明存在与黑素小体聚集相关的未分化肾上腺素能受体，以及与黑素小体分散相关的未分化胆碱能受体。
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