猪脂肪组织中脂肪分解的肾上腺素能控制。
Adrenergic control of lipolysis in swine adipose tissue.
作者信息
Mersmann H J
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(1):43-53. doi: 10.1016/0742-8413(84)90128-2.
Most potential adrenergic compounds did not stimulate lipolysis in swine adipose tissue slices. Most of the sympatholytic agents antagonized lipolysis. Most beta 1- and beta 2-adrenergic agonists were not active but many were active with rat adipose tissue. Catecholamines (epinephrine, norepinephrine and isoproterenol), the resorcinol containing beta 2-agonists (terbutaline, metaproterenol and fenoterol) and the beta 1-agonist, dobutamine were active. The beta 1-antagonists were generally more potent and efficacious than the beta 2-antagonists. The swine adipose tissue adrenoceptor was not readily classified as either beta 1- or beta 2-specific.
大多数潜在的肾上腺素能化合物不会刺激猪脂肪组织切片的脂肪分解。大多数抗交感神经药物会拮抗脂肪分解。大多数β1和β2肾上腺素能激动剂没有活性，但许多对大鼠脂肪组织有活性。儿茶酚胺（肾上腺素、去甲肾上腺素和异丙肾上腺素）、含间苯二酚的β2激动剂（特布他林、间羟异丙肾上腺素和非诺特罗）以及β1激动剂多巴酚丁胺具有活性。β1拮抗剂通常比β2拮抗剂更有效力和效能。猪脂肪组织肾上腺素能受体不易归类为β1或β2特异性。
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