Interaction of a beta-adrenergic partial agonist with its receptor in guinea-pig taenia caecum.
作者信息
Koike K, Takayanagi I
出版信息
Gen Pharmacol. 1984;15(1):47-50. doi: 10.1016/0306-3623(84)90079-x.
PMID:6141982
Abstract
Beta-adrenoceptor mechanisms in guinea-pig taenia caecum were studied by means of a receptor-binding technique. Hill plots of test drugs obtained from inhibition curves were linear with slopes which were equal to 1.00. pKi-values of isoprenaline and desisopropylprocaterol were in agreement with those pD2-values. pKi-value of carteolol was in agreement with its pA2-value. The beta-adrenoceptor is suggested to have two different sites; one can interact with the agonist and partial agonist and the other can interact with the antagonist and partial agonist.
摘要
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