人隐睾中促黄体生成素（LH）和促卵泡生成素（FSH）的受体及人绒毛膜促性腺激素（hCG）治疗的影响

Receptors for luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the human undescended testis and the effect of hCG-treatment.

作者信息

Läckgren G, Plöen L, Berg A A, Hansson V

出版信息

Int J Androl. 1983 Dec;6(6):520-32. doi: 10.1111/j.1365-2605.1983.tb00343.x.

DOI:10.1111/j.1365-2605.1983.tb00343.x

PMID:6142003

Abstract

Human testis tissue contains specific receptors for luteinizing hormone (LH) and follicle stimulating hormone (FSH) with Ka's of 1.5 and 1.6 X 10(9) M-1, respectively. Specific binding of [125I]hLH and [125I]hFSH was studied in testicular biopsies from 33 boys (4-16 years of age) with undescended testes and in 2 adult men with normally descended testes. Ten of the boys were treated with human chorionic gonadotrophin (hCG) and operated 1-4 days after the last injection. Samples from each testis were taken for histological evaluation. Specific binding of LH in biopsies from pre-pubertal boys (stage I) was low and differentiated Leydig cells could not be identified histologically. In later pubertal stages the LH binding increased and differentiated Leydig cells could now be recognized. hCG-treatment caused a highly significant increase (P less than 0.001) in the binding of LH without affecting FSH binding. The highest binding of FSH occurred during the onset of puberty. Treatment with hCG did not cause premature differentiation of Sertoli cells or germ cells, but appeared to stimulate Leydig cells.

摘要

人类睾丸组织含有促黄体生成素（LH）和促卵泡生成素（FSH）的特异性受体，其解离常数（Ka）分别为1.5和1.6×10⁹ M⁻¹。对33名患有隐睾症的男孩（4至16岁）以及2名睾丸位置正常的成年男性的睾丸活检组织进行了[¹²⁵I]hLH和[¹²⁵I]hFSH特异性结合的研究。其中10名男孩接受了人绒毛膜促性腺激素（hCG）治疗，并在最后一次注射后1至4天进行手术。从每个睾丸采集样本进行组织学评估。青春期前男孩（I期）活检组织中LH的特异性结合较低，组织学上无法识别分化的睾丸间质细胞。在青春期后期，LH结合增加，此时可以识别出分化的睾丸间质细胞。hCG治疗使LH的结合显著增加（P<0.001），而不影响FSH结合。FSH的最高结合出现在青春期开始时。hCG治疗并未导致支持细胞或生殖细胞过早分化，但似乎刺激了睾丸间质细胞。