Neftel K A, Käser H E, Vorkauf H
Int J Clin Pharmacol Ther Toxicol. 1984 Feb;22(2):118-9.
We tested the hypothesis that (1) beta 1-selective and nonselective beta adrenoceptor blockades have a different influence on stress-induced catecholamine overshoot, and (2) beta 1-selective blockade shifts the epinephrine/norepinephrine ratio in favor of norepinephrine. Seven violinists were investigated; each performed four times in public after ingesting different beta blockers. A significantly greater urinary norepinephrine/creatinine excretion was found with selective beta blockade than with nonselective. In addition during selective beta blockade creatinine excretion decreased significantly in comparison with nonselective blockade. This might be due to a higher concentration of circulating norepinephrine, stimulating alpha receptors in the renal vasculature.
（1）β1选择性和非选择性β肾上腺素能受体阻滞剂对应激诱导的儿茶酚胺过冲有不同影响；（2）β1选择性阻滞剂会使肾上腺素/去甲肾上腺素比值向有利于去甲肾上腺素的方向转变。我们对7名小提琴家进行了研究；每人在摄入不同的β受体阻滞剂后在公开场合表演4次。结果发现，与非选择性β受体阻滞剂相比，选择性β受体阻滞剂使尿去甲肾上腺素/肌酐排泄量显著增加。此外，与非选择性阻滞剂相比，在选择性β受体阻滞剂作用期间，肌酐排泄量显著降低。这可能是由于循环中去甲肾上腺素浓度较高，刺激了肾血管系统中的α受体。
