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四代人的精神异常与脑钙化

Psychiatric abnormality and brain calcification over four generations.

作者信息

Francis A, Freeman H

出版信息

J Nerv Ment Dis. 1984 Mar;172(3):166-70. doi: 10.1097/00005053-198403000-00006.

DOI:10.1097/00005053-198403000-00006
PMID:6142086
Abstract

An association between basal ganglia calcification and psychiatric abnormality, mainly schizophrenia, is described in three generations of a family; schizophrenia is also recorded in the previous generation. The mode of inheritance appears to be an X-linked dominant one. Unusual sensitivity to neuroleptics also occurred in four members of the family. No comparable family study is believed by the authors to have been reported previously.

摘要

在一个家族的三代人中描述了基底神经节钙化与精神异常(主要是精神分裂症)之间的关联;上一代也有精神分裂症的记录。遗传模式似乎是X连锁显性遗传。该家族的四名成员对神经阻滞剂也表现出异常敏感性。作者认为之前没有报道过类似的家族研究。

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