大麻与抗精神病药物在精神分裂症中的应用
Cannabis and neuroleptic agents in schizophrenia.
作者信息
Knudsen P, Vilmar T
出版信息
Acta Psychiatr Scand. 1984 Feb;69(2):162-74. doi: 10.1111/j.1600-0447.1984.tb02482.x.
Abstract
A description is given of 10 schizophrenic patients whose condition was acutely aggravated following cannabis use, despite verified adequate depot treatment with neuroleptics. It is concluded that cannabis use constitutes a risk factor for schizophrenic patients, and the hypothesis is suggested that there may exist a cannabis-neuroleptics antagonistic interaction. Recent research in cannabis pharmacokinetics is presented in support of this hypothesis.
摘要
本文描述了10例精神分裂症患者，尽管已证实使用长效抗精神病药物进行了充分的长效治疗，但在使用大麻后病情急剧加重。得出的结论是，使用大麻是精神分裂症患者的一个危险因素，并提出了一种假说，即可能存在大麻与抗精神病药物的拮抗相互作用。本文还介绍了近期关于大麻药代动力学的研究以支持这一假说。
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