Strukov A I, Kop'eva T N, Makarova O V
Arkh Patol. 1983;45(11):44-50.
The results of combined histochemical, immunomorphological, and immunological studies on biopsy, operation, and autopsy materials from 184 patients with rheumatoid arthritis, 41 patients with systemic lupus erythematosus, 66 patients with systemic sclerodermia. 35 patients with periarteritis nodosa are summarized. The main morphological changes in rheumatic diseases were found to be due to immunopathological reactions manifested as immune inflammation. According to the pattern of immunopathological mechanism, early and late immune inflammation manifested by humoral and cellular immunopathological reactions are distinguished. The predominant localization of lesions typical of each rheumatic disease, and the chronic self-maintaining pattern of inflammation are discussed.
对184例类风湿性关节炎患者、41例系统性红斑狼疮患者、66例系统性硬皮病患者和35例结节性多动脉炎患者的活检、手术及尸检材料进行组织化学、免疫形态学和免疫学联合研究的结果进行了总结。发现风湿性疾病的主要形态学变化是由表现为免疫炎症的免疫病理反应引起的。根据免疫病理机制模式，区分了由体液和细胞免疫病理反应表现出的早期和晚期免疫炎症。讨论了每种风湿性疾病典型病变的主要定位以及炎症的慢性自我维持模式。
