Crawley J N, Blumstein L K, Baldino F
Eur J Pharmacol. 1984 Jan 27;97(3-4):277-81. doi: 10.1016/0014-2999(84)90460-6.
Fominoben, a centrally acting antitussive, has been shown recently to bind to the brain benzodiazepine binding site and to antagonize pentylenetetrazol-induced seizures. The present study reports the ability of fominoben to produce anti-anxiety effects analogous to diazepam in a mouse exploratory model for anxiolytics. This action of fominoben was blocked by Ro15-1788, a benzodiazepine receptor antagonist, implicating a brain benzodiazepine binding site in this anxiolytic action of fominoben.
福尔米诺本是一种中枢性镇咳药，最近的研究表明它能与脑内苯二氮䓬结合位点结合，并拮抗戊四氮诱发的惊厥。本研究报告了福尔米诺本在一种用于抗焦虑药的小鼠探索模型中产生类似于地西泮的抗焦虑作用的能力。福尔米诺本的这一作用被苯二氮䓬受体拮抗剂Ro15 - 1788阻断，这表明福尔米诺本的这种抗焦虑作用涉及脑内苯二氮䓬结合位点。
