FitzGerald G A
Fed Proc. 1984 Apr;43(5):1379-81.
The concept of peripheral presynaptic regulation of neuronal norepinephrine (NE) release via alpha 2 adrenoreceptors has received extensive support from in vitro evidence. Despite this, the importance of such a system under physiological and pathophysiological conditions remains to be defined in humans. This largely reflects the limitations of using plasma NE as an index of neuronal amine release in vivo and the difficulties of interpreting the hemodynamic responses to adrenoreceptor agonists or antagonists administered in vivo. Efficient probes and sensitive indices of neuronal NE release are required to clarify the importance of peripheral presynaptic mechanisms in humans.
通过α2肾上腺素能受体对神经元去甲肾上腺素（NE）释放进行外周突触前调节的概念已得到体外证据的广泛支持。尽管如此，这种系统在生理和病理生理条件下的重要性在人类中仍有待确定。这在很大程度上反映了将血浆NE用作体内神经元胺释放指标的局限性，以及解释对体内给予的肾上腺素能受体激动剂或拮抗剂的血流动力学反应的困难。需要有效的探针和神经元NE释放的敏感指标来阐明外周突触前机制在人类中的重要性。
