Adamskaia E I, Babichev V N
Probl Endokrinol (Mosk). 1984 Jan-Feb;30(1):36-42.
Experiments on rats were made to examine the time course of changes in the content of dopamine, noradrenaline and serotonin in different areas of the hypothalamus during the estrous cycle and the effects of local administration of monoamines to the nuclear formations of the hypothalamus on luteinizing hormone (LH) release in intact and ovariectomized female rats. The amplitude of circadian fluctuations in the monoamine level was demonstrated to depend on the phase of the estrous cycle, with the minimal values in the preovulatory period. The differences were detected in the pattern of the response of pituitary gonadotrophics to the administration of monoamines to the hypothalamus depending on the function of the sexual glands. It was noted that noradrenergic innervation of the preoptic area and dopaminergic innervation of the arcuate nucleus exert a stimulant effect on the preovulatory release of LH and that serotoninergic innervation of the indicated areas has an inhibitory effect on the same process. Estradial was demonstrated to have a modulatory action on the studied effects of monoamines. The data obtained indicate the involvement of noradrenaline, dopamine and serotonin in the control of cyclic secretion of LH in female rats.
进行了大鼠实验，以研究动情周期期间下丘脑不同区域多巴胺、去甲肾上腺素和5-羟色胺含量的变化时间过程，以及向完整和去卵巢雌性大鼠下丘脑核团局部注射单胺对促黄体生成素（LH）释放的影响。结果表明，单胺水平的昼夜波动幅度取决于动情周期的阶段，在排卵前期达到最小值。根据性腺功能的不同，在下丘脑注射单胺后，垂体促性腺激素的反应模式存在差异。研究发现，视前区的去甲肾上腺素能神经支配和弓状核的多巴胺能神经支配对LH排卵前释放具有刺激作用，而上述区域的5-羟色胺能神经支配对同一过程具有抑制作用。已证明雌二醇对单胺的上述作用具有调节作用。所获得的数据表明，去甲肾上腺素、多巴胺和5-羟色胺参与了雌性大鼠LH周期性分泌的调控。
