Mösslacher H
Acta Med Austriaca. 1984;11(1):1-8.
Ischaemic heart disease is the main cause of death. Most of these deaths are sudden and occur within the first few hours of onset of symptoms and before the patient reaches the hospital. It is generally accepted, that sudden death is due to ventricular fibrillation. The aim of this presentation is to review the studies of long-term antiarrhythmic therapy and beta-blockade in the prevention of sudden cardiac death. Studies, in which a given antiarrhythmic drug was routinely applied, have universally failed to show any protective effect. However, when effective patient specific drugs are selected during programmed ventricular stimulation, long-term treatment in high risk patients may be beneficial. Recently suggestive evidence has been presented, that long-term beta-blockade is beneficial in preventing sudden death and reducing overall mortality in ischaemic heart disease although the antiarrhythmic properties of beta-blockers are relatively weak.
缺血性心脏病是主要死因。这些死亡大多是突发性的，发生在症状出现后的最初几个小时内，且在患者到达医院之前。人们普遍认为，猝死是由心室颤动引起的。本报告的目的是回顾长期抗心律失常治疗和β受体阻滞剂预防心脏性猝死的研究。常规应用特定抗心律失常药物的研究普遍未能显示出任何保护作用。然而，在程序性心室刺激期间选择有效的个体化药物时，对高危患者进行长期治疗可能有益。最近有提示性证据表明，长期使用β受体阻滞剂对预防缺血性心脏病猝死和降低总体死亡率有益，尽管β受体阻滞剂的抗心律失常作用相对较弱。
