两种β-肾上腺素能受体阻滞剂（美吲哚洛尔和阿替洛尔）对正常志愿者和原发性高血压患者血脂及血小板聚集的影响。
The effect of two beta-adrenoceptor blockers (mepindolol and atenolol) on blood lipids and platelet aggregation in normal volunteers and essential hypertensive patients.
作者信息
Luque Otero M, Fernandez Pinilla C, Escriba Polo A, Rodriguez Vazquez M, Martell Claros N, Fernandez-Cruz A
出版信息
Br J Clin Pharmacol. 1984 Mar;17(3):361-3. doi: 10.1111/j.1365-2125.1984.tb02355.x.
beta-adrenoceptor blocking agents are widely used as treatment of essential hypertension. We studied the action of a new non cardioselective beta-adrenoceptor blocker, mepindolol, comparing its effects on blood pressure, blood lipids and platelet aggregation with those of a cardioselective beta-adrenoceptor blocker, atenolol. Blood pressure fell significantly in the patients treated with both drugs. Triglycerides rose non-significantly only in volunteers treated with mepindolol. We did not find any significant changes in cholesterol, free fatty acids, lipoproteins and platelet aggregation.
β-肾上腺素能受体阻滞剂被广泛用于治疗原发性高血压。我们研究了一种新型非心脏选择性β-肾上腺素能受体阻滞剂美吲哚洛尔的作用，将其对血压、血脂和血小板聚集的影响与心脏选择性β-肾上腺素能受体阻滞剂阿替洛尔的影响进行了比较。两种药物治疗的患者血压均显著下降。仅在接受美吲哚洛尔治疗的志愿者中，甘油三酯略有升高。我们未发现胆固醇、游离脂肪酸、脂蛋白和血小板聚集有任何显著变化。
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