Braga P C, Tiengo M, Biella G, Dall'Oglio G, Fraschini F
Brain Res. 1984 Mar 26;296(1):177-80. doi: 10.1016/0006-8993(84)90528-6.
Eseroline is a new agent, derived from physostigmine but lacking in pseudocholinesterase activity, that possesses opioid properties in vivo and in vitro in cats and rodents. The electrophysiological effect of this drug has been investigated. Our findings show that Eseroline (5 mg/kg i.p.), suppresses the nociceptive responses evoked by noxious (mechanical and thermal) stimuli, without affecting the spontaneous firing of neurons in the thalamus of anesthetized rat. This effect starts about 5 min after the administration and lasts on average for about 60 min. Naloxone (1 mg/kg i.p.), injected 10 min before Eseroline, antagonized the antinociceptive action of this drug.
依色林是一种新制剂，由毒扁豆碱衍生而来，但缺乏假胆碱酯酶活性，在猫和啮齿动物体内外均具有阿片样特性。已对该药物的电生理效应进行了研究。我们的研究结果表明，依色林（腹腔注射5毫克/千克）可抑制有害（机械和热）刺激诱发的伤害性反应，而不影响麻醉大鼠丘脑神经元的自发放电。这种效应在给药后约5分钟开始，平均持续约60分钟。在依色林给药前10分钟注射纳洛酮（腹腔注射1毫克/千克）可拮抗该药物的抗伤害作用。
