Ventura H O, Messerli F H, Frohlich E D, Kobrin I, Oigman W, Dunn F G, Carey R M
Circulation. 1984 Jun;69(6):1142-5. doi: 10.1161/01.cir.69.6.1142.
Systemic, splanchnic, and renal hemodynamics, intravascular volume, and reflexive and endocrine changes were measured before and after a single dose of fenoldopam, a novel antihypertensive agent that acts through stimulation of specific dopamine receptors. A 13% reduction in mean arterial pressure was mediated by a fall in total peripheral resistance association with an increase in cardiac index, heart rate, stroke volume, left ventricular ejection rate, and circumferential fiber shortening. Renal blood flow increased, thereby reducing the renal vascular resistance by more than 40%. In contrast, splanchnic hemodynamics failed to change. Likewise, there were no changes in intravascular volume, plasma renin activity, or norepinephrine, serum aldosterone, or prolactin levels.
在单次给予新型抗高血压药物非诺多泮前后，测量了全身、内脏和肾血流动力学、血管内容量以及反射性和内分泌变化。非诺多泮通过刺激特定多巴胺受体发挥作用。平均动脉压降低了13%，这是由总外周阻力下降介导的，同时伴有心脏指数、心率、每搏输出量、左心室射血率和圆周纤维缩短增加。肾血流量增加，从而使肾血管阻力降低超过40%。相比之下，内脏血流动力学没有变化。同样，血管内容量、血浆肾素活性、去甲肾上腺素、血清醛固酮或催乳素水平也没有变化。
