[对H1组胺受体具有选择性拮抗活性的4-[苄基-(2-二甲基氨基乙基)氨基]嘧啶化合物]
[4-[Benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds with selective antagonistic activity against H1-histamine receptors].
作者信息
Mossini F, Maggiali C, Morini G, Impicciatore M, Morini G, Molina E
出版信息
Farmaco Sci. 1984 Mar;39(3):189-99.
PMID:6143687
Abstract
This paper describes the synthesis of 2- and 4-[benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds and their antihistaminic properties studied on isolated guinea-pig ileum. Calculated pA2 values show that the antihistaminic activity of 4-[p.methoxybenzyl-(2-dimethylaminoethyl)amino]pyrimidine is specific and potent (8-10 times higher than that of thonzylamine).
摘要
本文描述了2-和4-[苄基-(2-二甲基氨基乙基)氨基]嘧啶化合物的合成及其在离体豚鼠回肠上研究的抗组胺特性。计算得到的pA2值表明，4-[对甲氧基苄基-(2-二甲基氨基乙基)氨基]嘧啶的抗组胺活性具有特异性且很强（比苯茚胺高8至10倍）。
Zotero 插件