脊髓上对脊髓反射的紧张性影响以及氯丙嗪作用中的参与情况。

Supraspinal tonic influence on spinal reflexes and involvement in the effect of chlorpromazine.

作者信息

Hino M, Ono H, Fukuda H

出版信息

Gen Pharmacol. 1984;15(2):155-8. doi: 10.1016/0306-3623(84)90100-9.

Abstract

Chlorpromazine (CPZ) depressed mono-(MSR) and polysynaptic reflexes in anesthetized rats. The MSR remained unaltered after spinal transection (C1). After spinal transection, the inhibitory effect of CPZ on the MSR disappeared. After CPZ injection, spinal transection enhanced the MSR to pre-drug level. Reserpine pretreatment abolished the inhibitory effect of CPZ on the MSR. Phenoxybenzamine inhibited the MSR and, when pre-injected, markedly attenuated the effect of CPZ on the MSR. These results suggest that in anesthetized rats, CPZ blocks the alpha-adrenoceptor-mediated facilitatory component of the spontaneous tonic influence on the MSR.

摘要

氯丙嗪（CPZ）可抑制麻醉大鼠的单突触反射（MSR）和多突触反射。在C1水平进行脊髓横断后，MSR保持不变。脊髓横断后，CPZ对MSR的抑制作用消失。注射CPZ后，脊髓横断使MSR增强至用药前水平。利血平预处理消除了CPZ对MSR的抑制作用。酚苄明可抑制MSR，预先注射时可显著减弱CPZ对MSR的作用。这些结果表明，在麻醉大鼠中，CPZ阻断了α-肾上腺素能受体介导的对MSR的自发紧张性影响的易化成分。