[Interval therapy of migraine. Pharmacological bases].

A quite heterogenous variety of drugs is used for the prophylactic treatment of patients with severe migraine. These drugs may prove effective in preventing migraine attacks due to two different pharmacological effects: a reduction of platelets' aggregability and/or an effect on blood vessels tone. The latter effect may be characterized by a decrease in reactivity, i.e. vasoconstriction as well as an overshooting vasodilation is prevented. The vascular tone is stabilized.