Ramírez M, Alba F, Vives F, Mora F, Osorio C
Rev Esp Fisiol. 1983 Dec;39(4):351-6.
The participation of noradrenaline (NE) and serotonine (5-HT) in self-stimulation (SS) of the medial prefrontal cortex (MPC) in the rat has been studied. Three groups of rats with bilateral electrodes implanted into the MPC were used in these experiments. In one of the groups, electrodes were also implanted into the locus coeruleus. In the first group, the rats received systemic injections of the following drugs: clonidine (alpha-agonist), phenoxybenzamine (alpha-antagonist), isoproterenol (beta-agonist) and propranolol (beta-antagonist). In the second group, p-chlorophenylalanine (a 5-HT synthesis inhibitor) was administered intragastrically and SS measured during the following 16 days. In these two groups of rats and previous to every SS session, spontaneous motor activity (SM) was measured as control for non specific effects of the drugs. In a third group of rats, lesions of the locus coeruleus were performed unilaterally and SS measured in both prefrontal cortex during the following 16 days post-lesion. SS contralateral to the lesioned side served as control for non-specific effects of the lesions. After all these treatments, SS of the MPC was not specifically affected. Our results suggest the non participation of NE and 5-HT terminals in the neural substrates underlying SS of the MPC.
已经研究了去甲肾上腺素（NE）和5-羟色胺（5-HT）在大鼠内侧前额叶皮质（MPC）自我刺激（SS）中的参与情况。在这些实验中，使用了三组双侧电极植入MPC的大鼠。在其中一组中，电极也植入了蓝斑。在第一组中，大鼠接受了以下药物的全身注射：可乐定（α激动剂）、酚苄明（α拮抗剂）、异丙肾上腺素（β激动剂）和普萘洛尔（β拮抗剂）。在第二组中，胃内给予对氯苯丙氨酸（一种5-HT合成抑制剂），并在接下来的16天内测量SS。在这两组大鼠中，在每次SS实验之前，测量自发运动活动（SM）作为药物非特异性作用的对照。在第三组大鼠中，单侧损毁蓝斑，并在损毁后的接下来16天内测量双侧前额叶皮质的SS。损毁侧对侧的SS作为损毁非特异性作用的对照。经过所有这些处理后，MPC的SS没有受到特异性影响。我们的结果表明，NE和5-HT终末不参与MPC自我刺激的神经基质。
