肾上腺素和卡巴胆碱对海蟾蜍（Bufo marinus）肺中肺泡收缩细胞形态的影响。
Effects of adrenaline and carbachol on the morphology of alveolar contractile cells in the lung of the toad (Bufo marinus).
作者信息
Warton A, Goldie R G, Papadimitriou J M, Paterson J W
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(2):283-8. doi: 10.1016/0742-8413(84)90014-8.
Smooth muscle-like interstitial cells in toad (Bufo marinus) lung strips were examined by light and electron microscopy and subjected to morphometric analysis in an attempt to assess the effect of spasmogenic and relaxant agonists on contractile cells in peripheral airways. Carbachol (12.8 microM) caused a 43.6% reduction in contractile cell length compared to control, while adrenaline (100 microM) caused a 21.3% increase. The mean transverse and longitudinal-sectional area and perimeter of cell profiles were significantly greater in carbachol treated preparations than in control. In tissue that had relaxed after exposure to adrenaline, the mean area of longitudinally sectioned cells and the perimeter of cell profiles were significantly reduced.
通过光学显微镜和电子显微镜对蟾蜍（海蟾蜍）肺条中的平滑肌样间质细胞进行了检查，并进行了形态计量分析，以评估致痉剂和松弛剂激动剂对外周气道收缩细胞的影响。与对照组相比，卡巴胆碱（12.8微摩尔）使收缩细胞长度减少了43.6%，而肾上腺素（100微摩尔）使收缩细胞长度增加了21.3%。在经卡巴胆碱处理的制剂中，细胞轮廓的平均横截面积、纵截面积和周长均显著大于对照组。在暴露于肾上腺素后已松弛的组织中，纵向切片细胞的平均面积和细胞轮廓的周长显著减小。
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