Griffiths E C, McDermott J R, Smith A I
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(2):363-6. doi: 10.1016/0742-8413(84)90029-x.
The products formed from mammalian neurotensin by peptidases in two subcellular fractions from rat, mouse, dove, terrapin and goldfish brain were separated and identified using high-performance liquid chromatography. The main neurotensin metabolites were [1-8]-, [1-10]- and [1-7]-sequences; goldfish and terrapin brain fractions also produced [1-11]- and [1-12]-fragments. Avian neurotensin was cleaved by peptidases in rat and dove brain fractions to [1-8]-, [9-13]-, [1-10]- and [1-12]-fragments. Similar mechanisms of inactivation were found for both mammalian and avian neurotensins .
利用高效液相色谱法对大鼠、小鼠、鸽子、龟和金鱼大脑中两个亚细胞组分中的肽酶作用于哺乳动物神经降压素所形成的产物进行了分离和鉴定。主要的神经降压素代谢产物为[1-8]-、[1-10]-和[1-7]-序列；金鱼和龟的脑组分还产生了[1-11]-和[1-12]-片段。鸟类神经降压素在大鼠和鸽子脑组分中被肽酶切割成[1-8]-、[9-13]-、[1-10]-和[1-12]-片段。在哺乳动物和鸟类神经降压素中发现了相似的失活机制。
