Jennings K R, Steele R W, Starratt A N
Experientia. 1984 May 15;40(5):456-8. doi: 10.1007/BF01952383.
The effects of the calcium antagonist diltiazem on nerve and muscle in the cockroach Periplaneta americana were examined. Diltiazem was observed to inhibit myogenic and glutamate-induced contractions of the visceral muscle while having either a potentiating, an inhibiting or a biphasic effect against proctolin-induced contractions. Against the isolated nervous system, diltiazem induced an increase in spontaneous discharge activity, followed by nerve block. Injection of diltiazem into cockroaches produced behavioral and toxic effects.
