Spear G S, Caple M V, Sutherland L R
Exp Mol Pathol. 1984 Jun;40(3):295-310. doi: 10.1016/0014-4800(84)90047-9.
Unique alpha-cell crystals, a herpes-like virus, islet amyloidosis, and immunohistochemical reactions of islets are compared in the rodent, Octodon degus, in animals with ordinary and high circulating glucose levels. Results suggest that crystals, virus, and amyloid are independent of blood sugar and bear no obvious relation to one another, although each is more common in older than in young animals. The crystals do not react with anti-glucagon. In the presence of high blood glucose, qualitative histochemical studies demonstrated diminished islet insulin and an unusual reaction with anti-somatostatin: (1) paucity of the usual cells that stain darkly for somatostatin and (2) striking staining of intermediate hue in most islet cells and in (3) multitudes of cell nests in exocrine parenchyma. The intermediate staining reaction may represent a visible demonstration of the paracrine phenomenon.
在循环葡萄糖水平正常和较高的啮齿动物八齿鼠（Octodon degus）中，对独特的α细胞晶体、一种类疱疹病毒、胰岛淀粉样变以及胰岛的免疫组化反应进行了比较。结果表明，晶体、病毒和淀粉样变与血糖无关，彼此之间也无明显关联，尽管它们在老年动物中比在幼年动物中更为常见。这些晶体不与抗胰高血糖素发生反应。在高血糖情况下，定性组织化学研究显示胰岛胰岛素减少，并且与抗生长抑素出现异常反应：（1）通常对生长抑素染色深的细胞数量减少，（2）大多数胰岛细胞以及（3）外分泌实质中的大量细胞巢出现明显的中间色调染色。这种中间染色反应可能代表旁分泌现象的一种可见表现。
