可能参与不均一核RNA加工和聚腺苷酸化代谢的碱基特异性核糖核酸酶。

Base-specific ribonucleases potentially involved in heterogeneous nuclear RNA processing and poly(A) metabolism.

作者信息

Bachmann M, Schröder H C, Messer R, Müller W E

出版信息

FEBS Lett. 1984 Jun 4;171(1):25-30. doi: 10.1016/0014-5793(84)80453-6.

Abstract

Polyadenylation and splicing of heterogeneous nuclear RNA, two crucial steps in mRNA processing, are apparently enzymatically mediated processes. This contribution summarizes the properties and the presumed functions of the known poly(A) catabolic enzymes (endoribonuclease IV and V, 2',3'- exoribonuclease ) as well as those of the pyrimidine-specific endoribonucleases associated with snRNP -hnRNP complexes (endoribonuclease VII, acidic pI 4.1 endoribonuclease and poly(U)-specific U1 snRNP -nuclease).

摘要

异质核RNA的聚腺苷酸化和剪接是mRNA加工过程中的两个关键步骤，显然是酶介导的过程。本文综述了已知的聚（A）分解代谢酶（核糖核酸内切酶IV和V、2',3'-核糖核酸外切酶）以及与snRNP-hnRNP复合物相关的嘧啶特异性核糖核酸内切酶（核糖核酸内切酶VII、酸性pI 4.1核糖核酸内切酶和聚（U）特异性U1 snRNP-核酸酶）的特性和推测功能。