Nagai F, Nakao T
Food Chem Toxicol. 1984 May;22(5):361-4. doi: 10.1016/0278-6915(84)90364-8.
The activities of certain enzymes in the urine and tissues of rats given 2% sodium o- phenylphenate in the diet for 20 wk were examined. Urinary gamma-glutamyl transpeptidase (gamma GTP) decreased immediately after the start of feeding of the treated diet and its activity remained low for 20 wk. The gamma GTP and alkaline phosphatase (ALP) activities in kidney homogenate decreased to about 80% of the control at 20 wk, but G6PD activity was significantly increased; Na,K-ATPase was unchanged. On the other hand, the gamma GTP activity in the liver homogenate of treated rats was increased to about eight times that of the controls, the G6PD activity showed a significant increase, but the ALP and Na, K-ATPase activities were not significantly different from the control values. The glutathione concentration in the livers of treated rats was significantly reduced.
对饮食中添加2%邻苯基苯酚钠持续20周的大鼠的尿液和组织中某些酶的活性进行了检测。喂食处理过的饮食开始后，尿γ-谷氨酰转肽酶（γGTP）立即下降，其活性在20周内一直保持较低水平。20周时，肾脏匀浆中的γGTP和碱性磷酸酶（ALP）活性降至对照组的约80%，但葡萄糖-6-磷酸脱氢酶（G6PD）活性显著增加；钠钾-ATP酶活性无变化。另一方面，处理过的大鼠肝脏匀浆中的γGTP活性增加至对照组的约8倍，G6PD活性显著增加，但ALP和钠钾-ATP酶活性与对照值无显著差异。处理过的大鼠肝脏中的谷胱甘肽浓度显著降低。
