Macphail S, Paciucci P A, Stutman O
J Immunol. 1984 Jun;132(6):3205-10.
By using monoclonal antibodies to Thy-1, Lyt-2, and Qa-5 differentiation antigens, we demonstrated a heterogeneity of cytotoxic cells developed in allogeneic mixed lymphocyte responses that lyse tumor cells syngeneic with the responder cells. There are minimally two Thy-1+ populations, one of which is Lyt-2+ and the other Lyt-2-. There is probably also a Thy-1- population. Most of the Lyt-2- tumor killer cells are Qa-5+, and most of the Lyt-2+ tumor killer cells are Qa-5-.
通过使用针对Thy-1、Lyt-2和Qa-5分化抗原的单克隆抗体，我们证明了在同种异体混合淋巴细胞反应中产生的、能够裂解与反应细胞同基因的肿瘤细胞的细胞毒性细胞具有异质性。至少存在两个Thy-1+群体，其中一个是Lyt-2+，另一个是Lyt-2-。可能还存在一个Thy-1-群体。大多数Lyt-2-肿瘤杀伤细胞是Qa-5+，而大多数Lyt-2+肿瘤杀伤细胞是Qa-5-。
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