吸烟对血清蛋白组成及药物蛋白结合的影响。
Influence of smoking on serum protein composition and the protein binding of drugs.
作者信息
Benedek I H, Blouin R A, McNamara P J
出版信息
J Pharm Pharmacol. 1984 Mar;36(3):214-6. doi: 10.1111/j.2042-7158.1984.tb06947.x.
The influence of smoking an alpha 1-acid glycoprotein (alpha 1-AGP) and serum albumin concentrations and the protein binding of phenytoin and propranolol in healthy volunteers was investigated. alpha 1-AGP concentrations were found to be statistically different (P less than 0.05) in the smokers (mean = 84.3 mg dl-1) versus non-smokers (mean = 62.8 mg dl-1). There was a trend for lower serum albumin concentrations and lower fraction unbound of propranolol in the smokers. Smoking did not affect the protein binding of phenytoin.
研究了吸烟对健康志愿者α1-酸性糖蛋白（α1-AGP）和血清白蛋白浓度以及苯妥英和普萘洛尔蛋白结合的影响。发现吸烟者（均值 = 84.3 mg dl-1）与非吸烟者（均值 = 62.8 mg dl-1）的α1-AGP浓度在统计学上存在差异（P < 0.05）。吸烟者的血清白蛋白浓度和普萘洛尔的未结合分数有降低的趋势。吸烟不影响苯妥英的蛋白结合。
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