Chey W Y, Chang T M, Park H J, Lee K Y, Escoffery R, Chen Y F, Shah A N, Hamilton D, You C H, Manguy R
Ann Intern Med. 1984 Jul;101(1):7-13. doi: 10.7326/0003-4819-101-1-7.
In 18 patients with hypersecretion of acid, severe ulcer diathesis, and pancreatic islet cell tumor or hyperplasia, 14 had hypergastrinemia and 4 had normal plasma gastrin concentration. The neoplasms contained several gut peptides beside gastrin. The immunoreactive gastrin in the tumor extracts measured less than 7 ng/g, less than the amount previously reported. The extracts of each patient's tumor also contained a secretogogue other than gastrin that stimulated gastric acid secretion in rats. In addition, the plasma extracts of 2 patients also contained a secretogogue that stimulated acid secretion. After surgical resection of a recurrent metastatic tumor in 1 patient, basal acid secretion decreased from 13.9 to less than 1 meq/h, and the bioactivity of the plasma disappeared. These observations suggest the existence of a secretogogue that appears to be a protein in the pancreatic tumors of some patients with severe ulcer diathesis and hypersecretion.
在18例胃酸分泌过多、严重溃疡素质且患有胰岛细胞瘤或胰岛细胞增生的患者中，14例有高胃泌素血症，4例血浆胃泌素浓度正常。肿瘤中除了胃泌素还含有几种肠道肽。肿瘤提取物中的免疫反应性胃泌素含量低于7 ng/g，低于先前报道的水平。每位患者肿瘤的提取物中还含有一种除胃泌素外能刺激大鼠胃酸分泌的促分泌素。此外，2例患者的血浆提取物中也含有一种能刺激胃酸分泌的促分泌素。1例患者复发性转移性肿瘤手术切除后，基础胃酸分泌从13.9降至每小时低于1毫当量，血浆的生物活性消失。这些观察结果提示，在一些有严重溃疡素质和胃酸分泌过多的患者的胰腺肿瘤中存在一种似乎是蛋白质的促分泌素。
