[异烟肼聚合修饰物的毒理学]
[Toxicology of a polymerized modification of isonicotinic acid hydrazide].
作者信息
Ostrovskiĭ M M, Broĭtman A Ia, Shenderova R I, Evsiukov V I
出版信息
Polim Med. 1977;7(4):245-53.
PMID:614539
Abstract
The biologic side effects were studied of a polymer of isonicotinic acid hydrazide (PINH) synthesized on the basis of the copolymer vinylpyrrolidone and crotonaldehyde. The influence of dosage and conditions of administration as a functional and morphologic indicator in animals were also investigated. Threshold dosage and optimal conditions of administration in clinical practice are recommended.
摘要
对基于乙烯基吡咯烷酮和巴豆醛共聚物合成的异烟肼聚合物（PINH）的生物学副作用进行了研究。还研究了给药剂量和给药条件对动物功能和形态指标的影响。推荐了临床实践中的阈剂量和最佳给药条件。
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