Kimura S, Hattori Y, Kanno M
Arch Int Pharmacodyn Ther. 1984 Mar;268(1):46-58.
The effects of phenylephrine on force of contraction and on slow action potentials were studied in the cardiac muscles of the Japanese monkey (Macaca fuscata). 1) The concentration-response curves for the positive inotropic effect of phenylephrine in the left atria and right ventricular papillary muscles were shifted to the right by either prazosin (10(-7) M) or propranolol (10(-6) M), and were further shifted in the presence of both prazosin and propranolol. 2) Phenylephrine (10(-5) M) restored the tension development in the left atria and right ventricular papillary muscles which were depolarized and rendered inexcitable by elevating K+ concentration to 22 mM. The restored contractions with phenylephrine were abolished or diminished by either prazosin (10(-6) M), phenylephrine (10(-5) M) restored action potentials in 4 of 6 K+-depolarized right ventricular muscle preparations; the restored action potentials were abolished or diminished by prazosin (10(-6) M). These results indicate that alpha-adrenoceptors as well as beta-adrenoceptors are involved in inducing slow responses in the monkey heart.
研究了去氧肾上腺素对日本猕猴（食蟹猴）心肌收缩力和慢动作电位的影响。1）去氧肾上腺素对左心房和右心室乳头肌正性肌力作用的浓度-反应曲线，在哌唑嗪（10⁻⁷M）或普萘洛尔（10⁻⁶M）存在时向右移动，且在哌唑嗪和普萘洛尔同时存在时进一步右移。2）去氧肾上腺素（10⁻⁵M）恢复了左心房和右心室乳头肌的张力发展，这些肌肉因将钾离子浓度提高到22mM而发生去极化并失去兴奋性。去氧肾上腺素恢复的收缩被哌唑嗪（10⁻⁶M）消除或减弱；去氧肾上腺素（10⁻⁵M）使6个钾离子去极化的右心室肌肉标本中的4个恢复了动作电位；恢复的动作电位被哌唑嗪（10⁻⁶M）消除或减弱。这些结果表明，α-肾上腺素能受体以及β-肾上腺素能受体都参与了猕猴心脏慢反应的诱导。
