西拉唑啉对大鼠输精管的作用。
The actions of cirazoline on the rat vas deferens.
作者信息
Docherty J R, McGrath J C
出版信息
Br J Pharmacol. 1984 May;82(1):9-14. doi: 10.1111/j.1476-5381.1984.tb16436.x.
Abstract
The pre- and postsynaptic effects of the alpha 1-agonist cirazoline were assessed in epididymal and prostatic portions of the rat isolated vas deferens. Cirazoline produced a postsynaptic alpha 1-adrenoceptor mediated potentiation of the isometric contraction to single pulse field stimulation in both prostatic and epididymal portions. In epididymal portions, nifedipine (10 microM) greatly attenuated the postsynaptic alpha 1-receptor mediated potentiation of nerve mediated contractions, uncovering a presynaptic inhibitory action of cirazoline . No evidence was found for alpha 2-antagonism by cirazoline . It is concluded that the previously reported antagonism of the presynaptic inhibitory effects of clonidine was due to postsynaptic potentiation of nerve-mediated responses by cirazoline .
摘要
在大鼠离体输精管的附睾和前列腺部分评估了α1-激动剂西拉唑啉的突触前和突触后效应。西拉唑啉在前列腺和附睾部分均产生了突触后α1-肾上腺素能受体介导的对等长收缩至单脉冲场刺激的增强作用。在附睾部分，硝苯地平（10微摩尔）极大地减弱了突触后α1-受体介导的神经介导收缩的增强作用，揭示了西拉唑啉的突触前抑制作用。未发现西拉唑啉具有α2-拮抗作用。得出的结论是，先前报道的可乐定突触前抑制作用的拮抗是由于西拉唑啉对神经介导反应的突触后增强作用。
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