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海人酸和谷氨酸神经毒性与出生后发育的关系，特别涉及海马神经元

Kainate and glutamate neurotoxicity in dependence on the postnatal development with special reference to hippocampal neurons.

作者信息

Wolf G, Keilhoff G

出版信息

Brain Res. 1984 May;316(1):15-21. doi: 10.1016/0165-3806(84)90004-x.

DOI:10.1016/0165-3806(84)90004-x
PMID:6145510
Abstract

The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both kainate and glutamate exerted similar behavioral effects from postnatal day 15 onwards. No correlation appears between kainate/glutamate-induced behavioral changes and their neurodegenerative potency.

摘要

海马体CA3/CA4神经元对脑室内注射红藻氨酸的特殊易损性直到出生后第16天才在大鼠中出现。以同样方式应用的谷氨酸即使以大剂量给予成年动物，也未表现出类似的神经退行性体征。另外，从出生后第15天起，红藻氨酸和谷氨酸都产生了类似的行为影响。红藻氨酸/谷氨酸诱导的行为变化与其神经退行性效力之间似乎没有相关性。

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