Rizov N, Georgiev G
Probl Khig. 1977;3:141-8.
A prompt, readily executed method for chlororganic insecticides determination in human fatty tissue is developed. The analytical course includes sample extraction with hexane, liquid distributional extraction with acetonitrile, and purification through small aluminium dioxide column. Final determination is performed with gas-liquid chromatography using electron detector. The method is endowed with a very high sensibility ranging from 0.1 micron/kg for hexachlorcyclohexane to 0.8 micron/kg for methoxychlor. Attained is a mean analytical yield for heptachlorepoxide amounting to 94 per cent. Reproducibility is fully satisfactory at interval of dispersion of the single measurement 9 per cent; confidential interval of the mean - 3 per cent. The method is successfully applied in mass investigations of the general population for level of chlororganic insecticides' determination.
开发了一种用于测定人体脂肪组织中有机氯杀虫剂的快速、易于执行的方法。分析过程包括用己烷萃取样品、用乙腈进行液液分配萃取以及通过小氧化铝柱进行纯化。最终测定采用带电子检测器的气液色谱法进行。该方法具有很高的灵敏度,从六氯环己烷的0.1微克/千克到甲氧滴滴涕的0.8微克/千克不等。七氯环氧化物的平均分析产率达到94%。单次测量的分散区间为9%时,重现性完全令人满意;平均值的置信区间为3%。该方法已成功应用于普通人群有机氯杀虫剂含量测定的大规模调查中。