Green A P, Mangan F R, Thomson M J, Randall K E, Boyle E A
J Pharm Pharmacol. 1984 May;36(5):314-7. doi: 10.1111/j.2042-7158.1984.tb04381.x.
BRL 20459 is a novel compound which displays anti-inflammatory activity when applied topically in the croton oil and cantharadin rat ear inflammation models. The compound does not inhibit uv-induced erythema in the guinea-pig or granuloma formation in the cotton pellet test in the rat. BRL 20459 does not inhibit prostaglandin synthesis nor does it interact with corticosteroid receptors in the thymus. In contrast to hydrocortisone, BRL 20459 did not cause thymus involution or reduce body weight gain in rats. BRL 20459 would seem to have a different mechanism of action to hydrocortisone, but this mechanism is as yet unknown.
BRL 20459是一种新型化合物，在巴豆油和斑蝥素诱导的大鼠耳部炎症模型中局部应用时具有抗炎活性。该化合物不抑制豚鼠紫外线诱导的红斑，也不抑制大鼠棉球试验中的肉芽肿形成。BRL 20459不抑制前列腺素合成，也不与胸腺中的皮质类固醇受体相互作用。与氢化可的松不同，BRL 20459不会导致大鼠胸腺萎缩或体重增加。BRL 20459的作用机制似乎与氢化可的松不同，但该机制尚不清楚。
