PK 10139与奎尼丁：对大鼠和犬体内地高辛浓度的影响
PK 10139 and quinidine: interactions with digoxin concentrations in rats and dogs.
作者信息
Rougeot C, Jozefczak C, Mestre M, Le Fur G, Uzan A
出版信息
J Pharm Pharmacol. 1984 May;36(5):347-9. doi: 10.1111/j.2042-7158.1984.tb04393.x.
Abstract
Quinidine induced an increase in digoxin plasma concentrations in rats and dogs. PK 10139, an antiarrhythmic agent 10 times more potent than quinidine, did not change digoxin plasma concentrations in these species. The results indicate that PK 10139 could be associated with digoxin without risk of side-effects.
摘要
奎尼丁可使大鼠和犬的地高辛血浆浓度升高。PK 10139是一种抗心律失常药物，其效力比奎尼丁强10倍，在这些物种中不会改变地高辛血浆浓度。结果表明，PK 10139可与地高辛联用而无副作用风险。
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