Hypouricaemic effect after oral administration in chickens of polyethylene glycol-modified uricase entrapped in liposomes.

Liposomal-entrapped methoxypolyethyleneglycol (PEG) modified uricase was used to study the plasma urate lowering effect after its oral administration to chickens. Plasma uric acid concentrations fell gradually and were accompanied by a rise in plasma uricolytic activity. Serum from chickens given PEG-modified uricase liposomes did not react with native uricase in immunodiffusion plates. These results suggested the clinical usefulness of liposome-entrapped PEG modified uricase in the treatment of hyperuricaemia.