Gasco M R, Carlotti M E, Trotta M
J Pharm Sci. 1984 May;73(5):662-7. doi: 10.1002/jps.2600730518.
The tricyclic amines promazine, promethazine, chlorpromazine, triflupromazine, and trifluperazine form solid ion pairs with ATP in a 1:2 molar ratio. There is a good correlation between the measured Ksp and the apparent diffusion constants of the ion pairs with the critical micelle concentration (CMC) of the corresponding phenothiazines. Solid ion pairs are solubilized by phenothiazine micelles; the binding constants of ATP to drug micelles are calculated from solubility data at 25 degrees C and can be related to the CMC of the phenothiazines.
三环胺类药物丙嗪、异丙嗪、氯丙嗪、三氟丙嗪和三氟拉嗪能与ATP以1:2的摩尔比形成固体离子对。所测离子对的溶度积（Ksp）与相应吩噻嗪类药物临界胶束浓度（CMC）下离子对的表观扩散常数之间存在良好的相关性。固体离子对可被吩噻嗪类胶束增溶；ATP与药物胶束的结合常数可根据25℃时的溶解度数据计算得出，且与吩噻嗪类药物的CMC相关。
