家族性高胆固醇血症患者的心脏-肝脏移植
Heart-liver transplantation in a patient with familial hypercholesterolaemia.
作者信息
Starzl T E, Bilheimer D W, Bahnson H T, Shaw B W, Hardesty R L, Griffith B P, Iwatsuki S, Zitelli B J, Gartner J C, Malatack J J
出版信息
Lancet. 1984 Jun 23;1(8391):1382-3. doi: 10.1016/s0140-6736(84)91876-2.
Abstract
A girl aged 6 years 9 months with severe heart disease secondary to homozygous familial hypercholesterolaemia underwent orthotopic cardiac transplantation and her liver was replaced with the liver of the same donor. In the first 10 weeks after transplantation serum cholesterol fell to 270 mg/dl from preoperative concentrations of more than 1000 mg/dl.
摘要
一名6岁9个月大的女孩因纯合子家族性高胆固醇血症继发严重心脏病，接受了原位心脏移植，其肝脏被同一供体的肝脏所替代。移植后的前10周内，血清胆固醇从术前超过1000mg/dl降至270mg/dl。
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本文引用的文献
1
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.在WHHL兔中，极低密度脂蛋白和中间密度脂蛋白清除延迟，向低密度脂蛋白的转化增强。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5693-7. doi: 10.1073/pnas.79.18.5693.
2
Evolution of liver transplantation.肝移植的发展历程。
Hepatology. 1982 Sep-Oct;2(5):614-36. doi: 10.1002/hep.1840020516.
3
Portacaval shunt in patients with familial hypercholesterolemia.家族性高胆固醇血症患者的门腔分流术。
Ann Surg. 1983 Sep;198(3):273-83. doi: 10.1097/00000658-198309000-00004.
4
Characterization of hepatic low density lipoprotein binding and cholesterol metabolism in normal and homozygous familial hypercholesterolemic subjects.正常及纯合子家族性高胆固醇血症患者肝脏低密度脂蛋白结合及胆固醇代谢特征
J Clin Invest. 1984 Feb;73(2):429-36. doi: 10.1172/JCI111229.
5
Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia.有缺陷的脂蛋白受体与动脉粥样硬化。家族性高胆固醇血症动物模型的启示。
N Engl J Med. 1983 Aug 4;309(5):288-96. doi: 10.1056/NEJM198308043090507.
6
Enzymatic determination of total serum cholesterol.血清总胆固醇的酶法测定
Clin Chem. 1974 Apr;20(4):470-5.
7
Multilayer film elements for clinical analysis: applications to representative chemical determinations.用于临床分析的多层薄膜元件：在代表性化学测定中的应用
Clin Chem. 1978 Aug;24(8):1343-50.
8
Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor.家族性高胆固醇血症中的遗传异质性：影响低密度脂蛋白受体功能的两种不同突变的证据。
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