Jeevanandam M, Horowitz G D, Lowry S F, Brennan M F
Lancet. 1984 Jun 30;1(8392):1423-6. doi: 10.1016/s0140-6736(84)91929-9.
Metabolic abnormalities arising from malnutrition and malignancy are seen in patients with cancer cachexia. To discriminate between the effects of pure malnutrition and tumour-specific metabolic alterations, the kinetics of whole-body metabolism were determined in 7 untreated, malnourished cancer patients and in 11 patients with benign disease, also malnourished, by means of primed constant infusion of 15N-glycine. Patients in both groups received 500 kcal/day as 5% glucose solution without any nitrogen. Whole-body protein turnover was 32% and 35% higher in the cancer patients than in the non-cancer patients and starved normal subjects respectively. Similarly, the rate of protein synthesis was 35% and 54% higher in the cancer patients than in the non-cancer patients and starved normal subjects respectively. Our study supports the view that aberrations of host metabolism in patients with cancer cachexia are different from those in non-cancer patients suffering equivalent weight loss.
癌症恶病质患者会出现由营养不良和恶性肿瘤引起的代谢异常。为了区分单纯营养不良的影响和肿瘤特异性代谢改变，通过对7名未经治疗的营养不良癌症患者和11名同样营养不良的良性疾病患者进行15N-甘氨酸的单次注射持续输注，测定了全身代谢动力学。两组患者均接受500千卡/天的5%葡萄糖溶液，不含任何氮。癌症患者的全身蛋白质周转率分别比非癌症患者和饥饿的正常受试者高32%和35%。同样，癌症患者的蛋白质合成率分别比非癌症患者和饥饿的正常受试者高35%和54%。我们的研究支持这样一种观点，即癌症恶病质患者的宿主代谢异常与体重减轻相当的非癌症患者不同。
