一种具有双重作用的化合物对全血中血红蛋白氧解离曲线的修饰。
Modification of the haemoglobin oxygen dissociation curve in whole blood by a compound with dual action.
作者信息
Hyde R M, Livingstone D J, Patterson R A, Batchelor J F, King W R
出版信息
Lancet. 1984 Jul 7;2(8393):15-6. doi: 10.1016/s0140-6736(84)92000-2.
PMID:6145935
Abstract
2-Ethoxy-6-(5-tetrazolyl)xanthone reduces the oxygen affinity of blood by two mechanisms; firstly, by a direct effect on the haemoglobin molecule and secondly by maintaining levels of 2,3-diphosphoglycerate (DPG) in stored blood. This compound thus has potential as a blood storage additive which will improve the oxygen delivery of stored blood.
摘要
2-乙氧基-6-(5-四唑基)呫吨酮通过两种机制降低血液的氧亲和力；首先，通过对血红蛋白分子的直接作用，其次，通过维持储存血液中2,3-二磷酸甘油酸（DPG）的水平。因此，这种化合物有潜力作为一种血液储存添加剂，改善储存血液的氧输送。
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