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1
Inositol trisphosphate and diacylglycerol as second messengers.肌醇三磷酸和二酰甘油作为第二信使。
Biochem J. 1984 Jun 1;220(2):345-60. doi: 10.1042/bj2200345.
2
[Membrane receptors and the metabolism of phosphatidylinositols: inositol triphosphate and diacylglycerol as secondary transmitters of information].[膜受体与磷脂酰肌醇代谢：肌醇三磷酸和二酰基甘油作为信息的次级传递分子]
Acta Physiol Pol. 1988;39 Suppl 32:1-52.
3
Ernst Klenk Lecture, November 1985. Intracellular signalling through inositol trisphosphate and diacylglycerol.恩斯特·克伦克讲座，1985年11月。通过肌醇三磷酸和二酰基甘油的细胞内信号传导。
Biol Chem Hoppe Seyler. 1986 Jun;367(6):447-56.
4
Gonadotropin-releasing hormone (GnRH) rapidly stimulates the formation of inositol phosphates and diacyglycerol in rat granulosa cells: further evidence for the involvement of Ca2+ and protein kinase C in the action of GnRH.促性腺激素释放激素（GnRH）能迅速刺激大鼠颗粒细胞中肌醇磷酸和二酰甘油的形成：Ca2+和蛋白激酶C参与GnRH作用的进一步证据。
Endocrinology. 1986 Jun;118(6):2561-71. doi: 10.1210/endo-118-6-2561.
5
Inositol trisphosphate and diacylglycerol: two interacting second messengers.肌醇三磷酸和二酰甘油：两种相互作用的第二信使。
Annu Rev Biochem. 1987;56:159-93. doi: 10.1146/annurev.bi.56.070187.001111.
6
Second messengers involved in superoxide production by neutrophils. Function and metabolism.参与中性粒细胞产生超氧化物的第二信使。功能与代谢。
Hematol Oncol Clin North Am. 1988 Jun;2(2):185-200.
7
Rapid dephosphorylation of protein kinase C substrates by protein kinase A activators results from inhibition of diacylglycerol release.蛋白激酶A激活剂导致蛋白激酶C底物快速去磷酸化是由二酰基甘油释放受到抑制引起的。
J Biol Chem. 1989 Jul 5;264(19):11193-9.
8
Two phases of inositol polyphosphate and diacylglycerol production at fertilisation.受精时肌醇多磷酸和二酰基甘油产生的两个阶段。
FEBS Lett. 1986 Jan 20;195(1-2):347-51. doi: 10.1016/0014-5793(86)80191-0.
9
Mechanisms involved in alpha-adrenergic phenomena.α-肾上腺素能现象所涉及的机制。
Am J Physiol. 1985 Jun;248(6 Pt 1):E633-47. doi: 10.1152/ajpendo.1985.248.6.E633.
10
A new view of receptor action.受体作用的新观点。
Science. 1984 Apr 20;224(4646):271-4. doi: 10.1126/science.6143399.

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Calcium Signaling Dynamics in Vascular Cells and Their Dysregulation in Vascular Disease.血管细胞中的钙信号动力学及其在血管疾病中的失调
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Phosphatidylinositol 4-phosphate; A minor lipid with multiple personalities.磷脂酰肌醇4-磷酸：一种具有多种特性的次要脂质。
Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Jun;1870(5):159615. doi: 10.1016/j.bbalip.2025.159615. Epub 2025 Apr 20.
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Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5.人源KCNQ5的磷脂酰肌醇4,5-二磷酸激活机制
Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2416738122. doi: 10.1073/pnas.2416738122. Epub 2025 Apr 2.
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Multiple activities of sphingomyelin synthase 2 generate saturated fatty acid- and/or monounsaturated fatty acid-containing diacylglycerol.鞘磷脂合酶2的多种活性产生含饱和脂肪酸和/或单不饱和脂肪酸的二酰基甘油。
J Biol Chem. 2024 Dec;300(12):107960. doi: 10.1016/j.jbc.2024.107960. Epub 2024 Nov 5.
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Current Strategies to Guide the Antiplatelet Therapy in Acute Coronary Syndromes.急性冠状动脉综合征的抗血小板治疗指导策略。
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Phosphoinositide Signaling in Immune Cell Migration.免疫细胞迁移中的磷酯酰肌醇信号转导。
Biomolecules. 2023 Nov 24;13(12):1705. doi: 10.3390/biom13121705.
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Ca-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro.钙介导的信号通路：体外成功生成成熟且具有功能的干细胞衍生胰腺β细胞的一个有前景的靶点。
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Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential.血液癌症中失调的钙信号传导：潜在机制与治疗潜力
Front Oncol. 2022 Oct 18;12:1010506. doi: 10.3389/fonc.2022.1010506. eCollection 2022.
9
Metabolic routing maintains the unique fatty acid composition of phosphoinositides.代谢途径维持了磷酸肌醇独特的脂肪酸组成。
EMBO Rep. 2022 Jul 5;23(7):e54532. doi: 10.15252/embr.202154532. Epub 2022 Jun 16.
10
Nir1 constitutively localizes at ER-PM junctions and promotes Nir2 recruitment for PIP homeostasis.Nir1 持续定位于内质网-质膜连接处，并促进 Nir2 募集以维持 PIP 稳态。
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本文引用的文献

1
THE BIOCHEMISTRY OF THE INOSITOL LIPIDS.肌醇脂质的生物化学
Vitam Horm. 1964;22:57-79. doi: 10.1016/s0083-6729(08)60336-2.
2
Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices.乙酰胆碱对胰腺切片和大脑皮层切片中单个磷脂的磷酰基单位周转的影响。
Biochim Biophys Acta. 1955 Sep;18(1):102-10. doi: 10.1016/0006-3002(55)90013-5.
3
Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices.酶分泌以及胰腺切片磷脂中P32的掺入。
J Biol Chem. 1953 Aug;203(2):967-77.
4
Activation of sarcoplasmic reticular Ca2+ transport ATPase by phosphorylation of an associated phosphatidylinositol.通过相关磷脂酰肌醇的磷酸化激活肌浆网Ca2+转运ATP酶
EMBO J. 1983;2(9):1543-8. doi: 10.1002/j.1460-2075.1983.tb01621.x.
5
Stimulation of DNA synthesis any myo-inositol incorporation in mammalian cells.刺激哺乳动物细胞中的DNA合成及肌醇掺入。
J Cell Physiol. 1980 May;103(2):263-9. doi: 10.1002/jcp.1041030211.
6
Stimulus-secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown.兔中性粒细胞中的刺激-分泌偶联并非由磷脂酰肌醇分解介导。
Nature. 1980 Nov 20;288(5788):275-7. doi: 10.1038/288275a0.
7
Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism.佛波酯和血管加压素通过共同机制刺激DNA合成。
Nature. 1980 Oct 16;287(5783):607-12. doi: 10.1038/287607a0.
8
Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.血小板的磷脂酶A2和磷脂酶C活性。不同的底物特异性、钙需求、pH依赖性及细胞定位。
J Biol Chem. 1980 Nov 10;255(21):10227-31.
9
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.二酰基甘油对钙和磷脂依赖性蛋白激酶的激活作用及其与磷脂酰肌醇代谢的可能关系。
J Biol Chem. 1980 Mar 25;255(6):2273-6.
10
f-MetLeuPhe-induced phosphatidylinositol turnover in rabbit neutrophils is dependent on extracellular calcium.甲酰甲硫氨酰亮氨酰苯丙氨酸诱导的兔中性粒细胞磷脂酰肌醇周转依赖于细胞外钙。
FEBS Lett. 1980 Jan 28;110(1):115-8. doi: 10.1016/0014-5793(80)80036-6.

Inositol trisphosphate and diacylglycerol as second messengers.

作者信息

Berridge M J

出版信息

Biochem J. 1984 Jun 1;220(2):345-60. doi: 10.1042/bj2200345.

DOI:10.1042/bj2200345
PMID:6146314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153635/
Abstract
摘要